Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lofentanil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 12/20 | 0.96 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.96 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.96 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lofentanil SCHEMBL29361613 | 1.00 | OPRM1 (0.96) | OPRM1OPRK1OPRL1OPRD1CACNA1C | |
| Lofentanil SCHEMBL123003 | 1.00 | OPRM1 (0.96) | OPRM1OPRK1OPRL1OPRD1CACNA1C | |
| Lofentanil SCHEMBL26429 | 0.98 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1CACNA1C | |
| Lofentanil SCHEMBL1952939 | 0.98 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1CACNA1C | |
| Lofentanil SCHEMBL1649486 | 0.98 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1CACNA1C | |
| Lofentanil SCHEMBL11565496 | 0.98 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1CACNA1C | |
| SCHEMBL11567176 | 0.89 | OPRM1 (0.83) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL11567179 | 0.89 | OPRM1 (0.83) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL18730637 | 0.89 | OPRM1 (0.81) | OPRM1OPRK1OPRL1OPRD1CACNA1C | |
| SCHEMBL11565454 | 0.88 | OPRM1 (0.82) | OPRM1OPRK1OPRL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876897-B1 | RED COLORANT FREE OF COCHINEAL RED AND COMPOSITIONS COMPRISING THE SAME | UNILEVER GLOBAL IP LTD (GB) | 2023-12-20 | — | — | EP | claimed |