Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 6/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11561974 | 0.91 | HCAR3 (0.45) | GBA1AGTR1AGTR2CRHR1KCNH2 | |
| SCHEMBL12394221 | 0.87 | HCAR3 (0.46) | GBA1CRHR1KCNH2MAPTHCAR3 | |
| SCHEMBL11567147 | 0.84 | GBA1 (0.47) | GBA1CRHR1NPSR1CNR2TSHR | |
| SCHEMBL13879816 | 0.84 | HCAR3 (0.51) | GBA1CRHR1MAPTHCAR3 | |
| SCHEMBL11563472 | 0.77 | SLC6A2 (0.40) | GBA1AGTR1AGTR2CRHR1NPSR1 | |
| SCHEMBL20056973 | 0.77 | HCAR3 (0.57) | GBA1CRHR1MAPTHCAR3 | |
| SCHEMBL11567387 | 0.76 | GBA1 (0.48) | GBA1CRHR1KCNH2CNR2TSHR | |
| SCHEMBL15075696 | 0.76 | CYP2C19 (0.55) | GBA1KCNH2NPSR1NPC1TSHR | |
| SCHEMBL21388440 | 0.74 | HCAR3 (0.50) | GBA1CRHR1KCNH2MAPTHCAR3 | |
| SCHEMBL11564050 | 0.74 | LMNA (0.43) | CRHR1MAPTNPSR1TSHRHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000816-A1 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1979-02-21 | — | — | EP | disclosed |