SCHEMBL1156728

SCHEMBL1156728

O=C(Oc1cccc(-c2cccc3ccccc23)c1-c1cccc2ccccc12)Oc1cccc(-c2cccc3ccccc23)c1-c1cccc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.48
ADK P55263 1/20 0.48
ALDH1A1 P00352 5/20 0.45
HSD17B10 Q99714 3/20 0.45
GAA P10253 2/20 0.45
PGR P06401 1/20 0.45
PTGS1 P23219 1/20 0.45
MAPK1 P28482 1/20 0.45
KMT2A Q03164 4/20 0.44
MEN1 O00255 2/20 0.44
RAB9A P51151 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
POLB P06746 1/20 0.43
KDM4E B2RXH2 3/20 0.42
HPGD P15428 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
BCHE P06276 1/20 0.41
SLC6A3 Q01959 1/20 0.41
MAPT P10636 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1156729 0.89 GSK3B (0.47) GSK3BADKALDH1A1HSD17B10GAA
SCHEMBL2291363 0.88 ALDH1A1 (0.49) GSK3BADKALDH1A1HSD17B10GAA
SCHEMBL9138035 0.87 GSK3B (0.48) GSK3BADKALDH1A1HSD17B10GAA
SCHEMBL1156687 0.86 ALDH1A1 (0.47) GSK3BADKALDH1A1HSD17B10GAA
SCHEMBL246023 0.81 ALDH1A1 (0.44) ALDH1A1HSD17B10GAAPGRPTGS1
SCHEMBL30462997 0.81 ALDH1A1 (0.44) ALDH1A1HSD17B10GAAPGRPTGS1
SCHEMBL238319 0.80 HDAC8 (0.54) ALDH1A1HSD17B10GAAPGRPTGS1
SCHEMBL37865 0.80 ALDH1A1 (0.65) ALDH1A1HSD17B10GAAPGRPTGS1
SCHEMBL29901836 0.80 ALDH1A1 (0.65) ALDH1A1HSD17B10GAAPGRPTGS1
SCHEMBL1156688 0.80 ALDH1A1 (0.43) GSK3BADKALDH1A1HSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6734278-B2 MELT ESTER INTERCHANGE BAYER AKTIENGESELLSCHAFT (DE) 2004-05-11 US claimed
US-20030139564-A1 Production of polyester carbonates BAYER AKTIENGESELLSCHAFT (DE) 2003-07-24 US claimed
EP-3174935-B1 COPOLYCARBONATE COMPOUNDS WITH CYCLIC AND LINEAR OLIGOMERS AND IMPROVED OPTICAL PROPERTIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2023-06-21 EP disclosed
EP-3174934-B1 COPOLYCARBONATE COMPOUNDS WITH CYCLIC AND LINEAR OLIGOMERS AND IMPROVED RHEOLOGICAL PROPERTIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2023-06-14 EP disclosed
EP-3227374-B1 COPOLYCARBONATE COMPOUNDS WITH IMPROVED RHEOLOGICAL AND OPTICAL PROPERTIES CONTAINING DIGLYCEROLESTER COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2022-06-01 EP disclosed
US-10272654-B2 Polycarbonate composition having improved flame resistance for extrusion applications COVESTRO DEUTSCHLAND AG (DE) 2019-04-30 US disclosed
US-9676716-B2 Polycarbonate having improved thermal and mechanical properties and reduced coefficients of thermal expansion COVESTRO DEUTSCHLAND AG (DE) 2017-06-13 US disclosed
US-20150232644-A1 PRODUCTS WITH IMPROVED NON-FLAMMABILITY COVESTRO DEUTSCHLAND AG (DE) 2015-08-20 US disclosed
US-8969477-B2 Polycarbonate compositions having improved mechanical properties BAYER MATERIALSCIENCE AG (DE) 2015-03-03 US disclosed
US-8507635-B2 Modified polycarbonates having improved surface properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-08-13 US disclosed
US-8470934-B2 Polycarbonate compositions having improved surface hardness BAYER MATERIALSCIENCE AG (DE) 2013-06-25 US disclosed
US-5459225-A Ester interchange in antioxidant presence IDEMITSU PETROCHEMICAL CO., LTD. (JP) 1995-10-17 US disclosed
EP-0646613-A2 A branched polycarbonate and a process for producing the same IDEMITSU PETROCHEMICAL CO. LTD. (JP) 1995-04-05 EP disclosed
US-5349042-A Ester interchange and dechlorination with carbonation IDEMITSU PETROCHEMICAL CO., LTD. (JP) 1994-09-20 US disclosed
US-5276129-A Aromatic polycarbonates with excellent color tone, heat resistance and water resistance GE PLASTICS JAPAN, LTD. (JP) 1994-01-04 US disclosed
EP-0561363-A2 Process for producing polycarbonate IDEMITSU PETROCHEMICAL CO. LTD. (JP) 1993-09-22 EP disclosed
US-5187242-A Workable molding materials containing aliphatic carboxylic acids and aromatic diols as monomers, impact strenth, transparency GENERAL ELECTRIC COMPANY (US) 1993-02-16 US disclosed
US-5151491-A Nitrogen compound, a boric acid compound and a dihydroxy compound terminated with a monoalcohol GE PLASTICS JAPAN, LTD. (JP) 1992-09-29 US disclosed
EP-0434998-A2 Polycarbonate or polyestercarbonate resin compositions and preparing methods thereof GE PLASTICS JAPAN LIMITED (JP) 1991-07-03 EP disclosed
EP-0360578-A2 Process for the production of polycarbonates GE PLASTICS JAPAN LTD. (JP) 1990-03-28 EP disclosed