Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.55 |
| ▸ | PPARG | P37231 | 7/20 | 0.55 |
| ▸ | PPARD | Q03181 | 7/20 | 0.55 |
| ▸ | PPARA | Q07869 | 7/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | TLR2 | O60603 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | FABP4 | P15090 | 2/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.55 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tridecan-1-Ol SCHEMBL10889589 | 1.00 | TSHR (0.77) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Cetostearyl Alcohol SCHEMBL28381024 | 1.00 | TSHR (0.77) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Cetyl Alcohol SCHEMBL28576067 | 1.00 | TSHR (0.77) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Dodecanol SCHEMBL27935969 | 1.00 | TSHR (0.77) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| 1-Hexanol SCHEMBL3474518 | 1.00 | TSHR (0.77) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Dodecanol SCHEMBL28266069 | 0.97 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| 1-Pentanol SCHEMBL6569557 | 0.97 | SMN1; SMN2 (0.75) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Octanol SCHEMBL28196238 | 0.95 | TSHR (0.68) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| 1-Heptanol SCHEMBL25433349 | 0.92 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Acetic Acid SCHEMBL9650071 | 0.92 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000476-A1 | Process for the preparation of cyclopentadecanolide | HAARMANN & REIMER GMBH (DE) | 1979-02-07 | — | — | EP | claimed |
| EP-0000476-A1 | Process for the preparation of cyclopentadecanolide | HAARMANN & REIMER GMBH (DE) | 1979-02-07 | — | — | EP | disclosed |