Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.44 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3210914 | 0.82 | CYP1A2 (0.51) | NPFFR1NPFFR2OPRM1CYP1A2CYP2D6 | |
| SCHEMBL1035137 | 0.81 | OPRM1 (0.60) | NPFFR1NPFFR2OPRM1CYP1A2CYP2D6 | |
| SCHEMBL11455113 | 0.80 | OPRM1 (0.48) | NPFFR1NPFFR2OPRM1CYP1A2CYP2D6 | |
| SCHEMBL654160 | 0.80 | KDM4E (0.51) | NPFFR1NPFFR2OPRM1CYP1A2CYP2D6 | |
| SCHEMBL782996 | 0.78 | CYP1A2 (0.51) | NPFFR1NPFFR2CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL12756274 | 0.77 | NPFFR1 (0.45) | NPFFR1NPFFR2OPRM1CYP1A2CYP2D6 | |
| SCHEMBL4781784 | 0.75 | ATM (0.47) | NPFFR1NPFFR2OPRM1CTSKPOLB | |
| SCHEMBL13451571 | 0.75 | OPRM1 (0.44) | NPFFR1NPFFR2OPRM1CYP1A2CYP2D6 | |
| SCHEMBL11568412 | 0.75 | MAPT (0.56) | POLBGAAMAPTKDM4EKMT2A | |
| SCHEMBL11563820 | 0.75 | CA12 (0.47) | OPRM1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |
| US-3998834-A | ANALGESICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-12-21 | — | — | US | disclosed |