Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10499852 | 0.86 | CYP1A2 (0.54) | CYP1A2CYP2D6FAAHHDAC1CYP3A4 | |
| SCHEMBL3210914 | 0.85 | CYP1A2 (0.51) | CYP1A2CYP2D6HDAC1CYP3A4POLB | |
| SCHEMBL654160 | 0.82 | KDM4E (0.51) | CYP1A2CYP2D6HDAC1CYP3A4POLB | |
| SCHEMBL12756274 | 0.82 | NPFFR1 (0.45) | CYP1A2CYP2D6HDAC1CYP3A4POLB | |
| SCHEMBL4781784 | 0.81 | ATM (0.47) | POLBNPFFR1NPFFR2MEN1KMT2A | |
| SCHEMBL15054853 | 0.80 | FAAH (0.49) | CYP1A2CYP2D6FAAHHDAC1CYP3A4 | |
| SCHEMBL11455113 | 0.79 | OPRM1 (0.48) | CYP1A2CYP2D6HDAC1CYP3A4POLB | |
| SCHEMBL20224882 | 0.79 | CYP1A2 (0.52) | CYP1A2CYP2D6FAAHHDAC1CYP3A4 | |
| SCHEMBL11567708 | 0.78 | NPFFR1 (0.44) | CYP1A2CYP2D6HDAC1CYP3A4POLB | |
| SCHEMBL20070034 | 0.75 | CYP1A2 (0.49) | CYP1A2CYP2D6FAAHHDAC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721452-B1 | PROCESS FOR THE PREPARATION OF SUFENTANIL DERIVATIVES BY CARBENE ADDITION/AMINOLYSIS OF 4-PIPERIDONE | MALLINCKRODT INC (US) | 2001-06-20 | — | — | EP | claimed |
| EP-0721452-A1 | PROCESS FOR THE PREPARATION OF SUFENTANIL DERIVATIVES BY CARBENE ADDITION/AMINOLYSIS OF 4-PIPERIDONE | Mallinckrodt Chemical, Inc. (US) | 1996-07-17 | — | — | EP | claimed |
| US-5489689-A | CONDENSING A PIPERIDONE WITH A PRIMARY AMINE TO FORM A 4-AMINO-4-CARBOXYAMINOPIPERIDINE; HYDROLYSIS; CONDENSATION WITH A MESYLATE CONTAINING A PHENYL, THIENYL OR 4-ETHYL-4,5-DIHYDRO-5-OXO-1H-TETRAZPINE | MALLINCKRODT CHEMICAL, INC. (US) | 1996-02-06 | — | — | US | claimed |
| WO-1995009152-A1 | PROCESS FOR THE PREPARATION OF SUFENTANIL DERIVATIVES BY CARBENE ADDITION/AMINOLYSIS OF 4-PIPERIDONE | MALLINCKRODT CHEMICAL, INC. (US) | 1995-04-06 | — | — | WO | claimed |
| EP-2616464-B1 | IMPROVED PROCESS FOR THE PREPARATION OF A PRECURSOR OF SUFENTANIL BASE | MALLINCKRODT LLC (US) | 2018-01-03 | — | — | EP | disclosed |
| US-8946433-B2 | Process for the preparation of sufentanil base and related compounds | MALLINCKRODT LLC (US) | 2015-02-03 | — | — | US | disclosed |
| EP-2455377-B1 | Synthesis of fentanyl analogs | HAMELN RDS GMBH (DE) | 2014-07-09 | — | — | EP | disclosed |
| EP-2616464-A2 | IMPROVED PROCESS FOR THE PREPARATION OF SUFENTANIL BASE AND RELATED COMPOUNDS | Mallinckrodt LLC (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20120071659-A1 | Process for the Preparation of Sufentanil Base and Related Compounds | MALLINCKRODT LLC (US) | 2012-03-22 | — | — | US | disclosed |
| WO-2012037309-A2 | IMPROVED PROCESS FOR THE PREPARATION OF SUFENTANIL BASE AND RELATED COMPOUNDS | MALLINCKRODT LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| US-20080312448-A1 | Process for Synthesizing Remifentanil | MALLINCKRODT INC. | 2008-12-18 | — | — | US | disclosed |
| US-20080312448-A1 | Process for Synthesizing Remifentanil | MALLINCKRODT INC. | 2008-12-18 | — | — | US | disclosed |
| EP-0721452-B1 | PROCESS FOR THE PREPARATION OF SUFENTANIL DERIVATIVES BY CARBENE ADDITION/AMINOLYSIS OF 4-PIPERIDONE | MALLINCKRODT INC (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-0721452-A1 | PROCESS FOR THE PREPARATION OF SUFENTANIL DERIVATIVES BY CARBENE ADDITION/AMINOLYSIS OF 4-PIPERIDONE | Mallinckrodt Chemical, Inc. (US) | 1996-07-17 | — | — | EP | disclosed |
| US-5489689-A | CONDENSING A PIPERIDONE WITH A PRIMARY AMINE TO FORM A 4-AMINO-4-CARBOXYAMINOPIPERIDINE; HYDROLYSIS; CONDENSATION WITH A MESYLATE CONTAINING A PHENYL, THIENYL OR 4-ETHYL-4,5-DIHYDRO-5-OXO-1H-TETRAZPINE | MALLINCKRODT CHEMICAL, INC. (US) | 1996-02-06 | — | — | US | disclosed |
| WO-1995009152-A1 | PROCESS FOR THE PREPARATION OF SUFENTANIL DERIVATIVES BY CARBENE ADDITION/AMINOLYSIS OF 4-PIPERIDONE | MALLINCKRODT CHEMICAL, INC. (US) | 1995-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071659-A1 | Process for the Preparation of Sufentanil Base and Related Compounds | SNRPD1, SNRPD2, SNRPA1 | CYP1A2 689/4885CYP2D6 431/4885FAAH 2016/4885 |
| US-20080312448-A1 | Process for Synthesizing Remifentanil | OPRM1, OPRK1, OPRD1 | CYP1A2 13/4885CYP2D6 55/4885FAAH 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.