Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL1668128 | 0.97 | MAPT (0.33) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL451439 | 0.92 | CA12 (0.32) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL8345918 | 0.89 | PAOX (0.38) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL16075892 | 0.89 | KDM4E (0.33) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL10885284 | 0.89 | CA12 (0.31) | SMN1; SMN2 | |
| SCHEMBL11028285 | 0.89 | KDM4E (0.33) | MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL4312171 | 0.87 | ALDH1A1 (0.40) | MAPTKDM4EALOX15 | |
| SCHEMBL25636519 | 0.87 | PAOX (0.37) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL6242410 | 0.85 | CA12 (0.35) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL8940029 | 0.85 | CA12 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000215-A1 | Low-phosphate detergent composition for fabric washing | Procter & Gamble European Technical Center (BE) | 1979-01-10 | — | — | EP | disclosed |