Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL11568005 | 0.97 | MAPT (0.32) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL451439 | 0.94 | CA12 (0.32) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL8345918 | 0.92 | PAOX (0.38) | MAPTKDM4EALOX15SMN1; SMN2CYP1A2 | |
| SCHEMBL10885284 | 0.92 | CA12 (0.31) | SMN1; SMN2 | |
| SCHEMBL11028285 | 0.92 | KDM4E (0.33) | MAPTKDM4EALOX15SMN1; SMN2 | |
| SCHEMBL16075892 | 0.92 | KDM4E (0.33) | MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL4312171 | 0.89 | ALDH1A1 (0.40) | MAPTKDM4EALOX15CYP1A2CYP2C9 | |
| SCHEMBL6242410 | 0.88 | CA12 (0.35) | MAPTKDM4EALOX15SMN1; SMN2CYP1A2 | |
| SCHEMBL8940029 | 0.88 | CA12 (0.35) | CYP2C9 | |
| Trolamine SCHEMBL15733301 | 0.87 | CYP1A2 (0.33) | MAPTKDM4EALOX15SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130281944-A1 | TRANSDERMAL THERAPEUTIC SYSTEM (TTS) COMPRISING ROTIGOTINE | RATIOPHARM GMBH (DE) | 2013-10-24 | — | — | US | claimed |
| US-20080166661-A1 | Method for forming a fine pattern in a semiconductor | HYNIX SEMICONDUCTOR INC. (KR) | 2008-07-10 | — | — | US | claimed |
| EP-1509195-A1 | SUNSCREEN COSMETIC COMPOSITIONS STORAGE STABILIZED WITH MALONATE SALTS | UNILEVER PLC (GB) | 2005-03-02 | — | — | EP | claimed |
| US-20040185015-A1 | Sunscreen cosmetic compositions storage stabilized with malonate salts | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-09-23 | — | — | US | claimed |
| WO-2003099250-A1 | SUNSCREEN COSMETIC COMPOSITIONS STORAGE STABILIZED WITH MALONATE SALTS | UNILEVER PLC (GB) | 2003-12-04 | — | — | WO | claimed |
| EP-0070077-B2 | LIGHT-DUTY DETERGENT GRANULE COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 1992-11-04 | — | — | EP | claimed |
| EP-0178495-B1 | METHOD OF HIGH CONTRAST POSITIVE PHOTORESIST DEVELOPING | MicroSi, Inc. (a Delaware corporation) (US) | 1990-03-21 | — | — | EP | claimed |
| US-4645663-A | Process for preparing a hair dye or hair bleach composition; a composition for use in this process; and the use of said composition to dye or bleach hair | SOCIETE ANONYME DITE: L'OREAL (FR) | 1987-02-24 | — | — | US | claimed |
| US-4613561-A | FLUOROCARBON OR CARBOXYLATED SURFACTANT | Lewis, James Marvin (US) | 1986-09-23 | — | — | US | claimed |
| EP-0178495-A2 | Method of high contrast positive photoresist developing | MicroSi, Inc. (a Delaware corporation) (US) | 1986-04-23 | — | — | EP | claimed |
| US-4323582-A | Method of treating animals and humans for internal and external parasites | SIEGEL, NORMAN H. (US) | 1982-04-06 | — | — | US | claimed |
| CN-118050455-A | Analysis method for amine liquid composition | 中国石油天然气股份有限公司 | 2024-05-17 | — | — | CN | disclosed |
| EP-4362991-A1 | INSTANT ACTION AEROSOL FOR AIR SANITIZATION AND DISINFECTION | Reckitt Benckiser Llc (US) | 2024-05-08 | — | — | EP | disclosed |
| WO-2023244242-A1 | INSTANT ACTION AEROSOL FOR AIR SANITIZATION AND DISINFECTION | RECKITT BENCKISER LLC (US) | 2023-12-21 | — | — | WO | disclosed |
| WO-2023275510-A1 | INSTANT ACTION AEROSOL FOR AIR SANITIZATION AND DISINFECTION | RECKITT BENCKISER LLC (US) | 2023-01-05 | — | — | WO | disclosed |
| US-4153633-A | HYDROLYSIS | RHODIA, INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4043752-A | Phenylazoaminophenylpyrazole acid dye solutions containing two nonionic surfactants | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-08-23 | — | — | US | disclosed |
| US-3999957-A | THERMOSETTING RESINS | PENNWALT CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |
| US-3968110-A | PHENYL | LEVER BROTHERS COMPANY (US) | 1976-07-06 | — | — | US | disclosed |
| US-3965254-A | Compositions for the treatment of calcific tumors | THE PROCTER & GAMBLE COMPANY (US) | 1976-06-22 | — | — | US | disclosed |