Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677993 | 0.79 | LMNA (0.37) | LMNATDP1POLBCTDSP1KDM4E | |
| SCHEMBL8996568 | 0.75 | TDP1 (0.41) | LMNATDP1POLBCTDSP1KDM4E | |
| SCHEMBL3192520 | 0.75 | TDP1 (0.38) | LMNATDP1POLBCTDSP1KDM4E | |
| SCHEMBL9298779 | 0.75 | ALDH1A1 (0.38) | LMNATDP1POLBCTDSP1KDM4E | |
| SCHEMBL4157002 | 0.72 | LMNA (0.60) | LMNAKDM4EALDH1A1TP53TSHR | |
| SCHEMBL4157000 | 0.72 | LMNA (0.60) | LMNAKDM4EALDH1A1TP53TSHR | |
| SCHEMBL1451358 | 0.70 | POLB (0.57) | LMNATDP1POLBKDM4EALDH1A1 | |
| SCHEMBL10050523 | 0.70 | POLB (0.57) | LMNATDP1POLBKDM4EALDH1A1 | |
| SCHEMBL19318635 | 0.70 | POLB (0.57) | LMNATDP1POLBKDM4EALDH1A1 | |
| SCHEMBL9605855 | 0.70 | POLB (0.57) | LMNATDP1POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176220-A | COORDINATION CATALYST | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1979-11-27 | — | — | US | claimed |
| US-4176220-A | COORDINATION CATALYST | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1979-11-27 | — | — | US | disclosed |
| US-4068063-A | Catalyst composition for ring-opening polymerization of norbornene derivatives and process for polymerizing same | JAPAN SYNTHETIC RUBBER CO., LTD. (JA) | 1978-01-10 | — | — | US | disclosed |