Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10801725 | 0.90 | FOLH1 (0.59) | EPHX2NPC1RAB9AFOLH1NAAA | |
| SCHEMBL8975695 | 0.90 | FOLH1 (0.59) | EPHX2NPC1RAB9AFOLH1NAAA | |
| SCHEMBL10801036 | 0.89 | FOLH1 (0.60) | FOLH1NAAAHDAC3HDAC4HDAC1 | |
| SCHEMBL11544593 | 0.89 | FOLH1 (0.60) | FOLH1NAAAHDAC3HDAC4HDAC1 | |
| SCHEMBL11576579 | 0.88 | FOLH1 (0.60) | FOLH1NAAAHDAC3HDAC4HDAC1 | |
| SCHEMBL29775626 | 0.85 | ITGB3 (0.53) | ACEHPGD | |
| SCHEMBL24130553 | 0.83 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9AFOLH1GAA | |
| SCHEMBL9829488 | 0.83 | SLC1A2 (0.53) | LMNAACEHPGD | |
| SCHEMBL24130554 | 0.83 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9AFOLH1GAA | |
| SCHEMBL9829492 | 0.83 | SLC1A2 (0.53) | LMNAACEHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4166184-A | 2H-IMIDAZOLE-2-THIONE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-08-28 | — | — | US | disclosed |