Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iloperidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | DRD4 | P21917 | 1/20 | 1.00 |
| ▸ | ACHE | P22303 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | CCKBR | P32239 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iloperidone SCHEMBL29374709 | 1.00 | ABCB11 (1.00) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL28132950 | 0.99 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1804111 | 0.99 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1805470 | 0.99 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL28003560 | 0.99 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1802619 | 0.99 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL4534147 | 0.98 | ABCB11 (0.97) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1803151 | 0.98 | ABCB11 (0.97) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1801974 | 0.98 | ABCB11 (0.95) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL1545106 | 0.98 | ABCB11 (0.95) | ABCB11CHRM2HTR1AADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9182 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| US-12606869-B2 | Methods for the administration of iloperidone | Vanda Pharmaceutials Inc. (US) | 2026-04-21 | — | — | US | claimed |
| EP-4725483-A1 | COMBINATION COMPRISING AT LEAST ONE 5-HT2A RECEPTOR ANTAGONIST AND AT LEAST ONE 5-HT3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE | Université de Bordeaux (FR) | 2026-04-15 | — | — | EP | claimed |
| US-20260083759-A1 | Combinations Comprising Psychedelics for the Treatment of Schizophrenia and Other Neuropsychiatric and Neurologic Disorders | HADASIT MED RES SERVICE (IL) | 2026-03-26 | — | — | US | claimed |
| US-20260048062-A1 | FUSED AMINO PYRIMIDINE COMPOUNDS FOR TREATMENT OF PSYCHOSIS AND PSYCHOTIC DISORDERS | OVID THERAPEUTICS INC (US) | 2026-02-19 | — | — | US | claimed |
| US-12544367-B2 | Method of treatment of schizophrenia | VANDA PHARMACEUTICALS INC. (US) | 2026-02-10 | — | — | US | claimed |
| US-12544338-B2 | Solid or semisolid lipid based dosage form stabilization through curing and addition of low HLB surfactant(s) | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2026-02-10 | — | — | US | claimed |
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| US-12527754-B2 | Methods and compositions for preventing and treating metabolic syndrome induced by antipsychotic treatment and related diseases and conditions | TUFTS MEDICAL CENTER, INC. (US) | 2026-01-20 | — | — | US | claimed |
| WO-2000023057-A2 | ATYPICAL ANTIPHSYCHOTIC IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITOR FOR IMPROVING COGNITION | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-04-27 | — | — | WO | claimed |
| US-5955459-A | Fatty acid-antipsychotic compositions and uses thereof | NEUROMEDICA, INC. (US) | 1999-09-21 | — | — | US | claimed |
| WO-1999026661-A1 | A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA | PROTARGA INC. (US) | 1999-06-03 | — | — | WO | claimed |
| WO-1999021422-A1 | TREATMENT OF SCHIZOPHRENIA WITH AMPAKINES AND NEUROLEPTICS | CORTEX PHARMACEUTICALS, INC. (US) | 1999-05-06 | — | — | WO | claimed |
| EP-0402644-B1 | N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-08-16 | — | — | EP | claimed |
| US-5364866-A | Side effect reduction | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-11-15 | — | — | US | claimed |
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | claimed |
| EP-0542136-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | claimed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | claimed |
| EP-0402644-A1 | N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-12-19 | — | — | EP | claimed |