Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iloperidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.95 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.95 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.95 |
| ▸ | HTR1A | P08908 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.95 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.95 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.95 |
| ▸ | DRD1 | P21728 | 1/20 | 0.95 |
| ▸ | DRD4 | P21917 | 1/20 | 0.95 |
| ▸ | ACHE | P22303 | 1/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.95 |
| ▸ | HTR2C | P28335 | 1/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.95 |
| ▸ | CCKBR | P32239 | 1/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.95 |
| ▸ | HRH1 | P35367 | 1/20 | 0.95 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.95 |
| ▸ | DRD3 | P35462 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iloperidone SCHEMBL4534147 | 0.98 | ABCB11 (0.97) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1803151 | 0.98 | ABCB11 (0.97) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL29374709 | 0.98 | ABCB11 (1.00) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL115755 | 0.98 | ABCB11 (1.00) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1802619 | 0.97 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1804111 | 0.97 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL28003560 | 0.97 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1805470 | 0.97 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL28132950 | 0.97 | ABCB11 (0.98) | ABCB11CHRM2HTR1AADRA2ACHRM1 | |
| Iloperidone SCHEMBL1803510 | 0.95 | ABCB11 (0.92) | ABCB11CHRM2HTR1AADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012063269-A2 | PROCESS FOR PREPARING ILOPERIDONE | CADILA HEALTHCARE LIMITED (IN) | 2012-05-18 | — | — | WO | claimed |
| WO-2011055188-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ILOPERIDONE | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2011-05-12 | — | — | WO | claimed |
| WO-2012063269-A2 | PROCESS FOR PREPARING ILOPERIDONE | CADILA HEALTHCARE LIMITED (IN) | 2012-05-18 | — | — | WO | disclosed |
| WO-2011055188-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ILOPERIDONE | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2011-05-12 | — | — | WO | disclosed |