Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 3/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11577383 | 0.89 | HRH4 (0.46) | HPGDL3MBTL1AHRMETAP1NOTUM | |
| SCHEMBL2375779 | 0.89 | HPGD (0.52) | HPGDL3MBTL1AHRNOTUMAR | |
| SCHEMBL11564826 | 0.89 | MAPK1 (0.47) | HPGDL3MBTL1AHRMETAP1DRD2 | |
| SCHEMBL7112749 | 0.86 | AR (0.41) | HPGDL3MBTL1AHRMETAP1NOTUM | |
| SCHEMBL7115732 | 0.82 | MAPT (0.40) | HPGDCYP3A4CYP2D6MAPTTP53 | |
| SCHEMBL1988800 | 0.82 | CYP2C9 (0.45) | HPGDL3MBTL1AHRNOTUMAR | |
| SCHEMBL10463438 | 0.82 | AHR (0.50) | AHRMETAP1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8817067 | 0.81 | AHR (0.58) | AHRMETAP1DRD2DRD4CYP1A2 | |
| SCHEMBL10646312 | 0.79 | HRH4 (0.45) | HPGDL3MBTL1AHRMETAP1NOTUM | |
| SCHEMBL6287157 | 0.78 | MAOA (0.54) | AHRMETAP1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4118572-A | CNS DEPRESSANTS, NEUROLEPTIC AGENTS, SCHIZOPHRENIA, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1978-10-03 | — | — | US | disclosed |
| US-4105664-A | Dibenz[b,f]oxepin derivatives | HOFFMANN-LA ROCHE INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4100173-A | DEPRESSANTS, SCHIZOPHRENIA, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1978-07-11 | — | — | US | disclosed |
| US-4091023-A | ANTISCHIZOPHRENIA AGENTS, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1978-05-23 | — | — | US | disclosed |
| US-4032525-A | CNS DEPRESSANTS, NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1977-06-28 | — | — | US | disclosed |