Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HRH2 | P25021 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11577256 | 0.89 | HPGD (0.45) | HPGDL3MBTL1MAOBMAOADRD2 | |
| SCHEMBL11564826 | 0.88 | MAPK1 (0.47) | HPGDL3MBTL1MAOBMAOADRD2 | |
| SCHEMBL4427203 | 0.81 | MAOA (0.61) | HPGDMAOBMAOACYP1A2CYP3A4 | |
| SCHEMBL5642473 | 0.81 | MAOB (0.48) | HPGDL3MBTL1MAOBMAOAMEN1 | |
| SCHEMBL10844098 | 0.81 | AHR (0.49) | HPGDL3MBTL1MAOBMAOATDP1 | |
| SCHEMBL10462362 | 0.81 | MAOB (0.52) | HPGDL3MBTL1MAOBMAOADRD2 | |
| SCHEMBL8815141 | 0.80 | MAOA (0.65) | MAOBMAOADRD2DRD4CYP1A2 | |
| SCHEMBL11577383 | 0.79 | HRH4 (0.46) | HPGDL3MBTL1MAOBMAOAHRH4 | |
| SCHEMBL1988800 | 0.78 | CYP2C9 (0.45) | HPGDL3MBTL1MAOBMAOATDP1 | |
| SCHEMBL10646312 | 0.78 | HRH4 (0.45) | HPGDL3MBTL1HRH4ARLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921359-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921359-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921359-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2324032-B1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS INC (US) | 2014-10-01 | — | — | EP | disclosed |
| EP-2324032-B1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS INC (US) | 2014-10-01 | — | — | EP | disclosed |
| US-20130317014-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. | 2013-11-28 | — | — | US | disclosed |
| US-8450308-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450308-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450308-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110218192-A1 | Inhibitors Of Beta-Secretase | VITAE PHARMACEUTICALS, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
| US-20050148577-A1 | 1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
| US-20050130956-A1 | 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-06-16 | — | — | US | disclosed |
| US-5140027-A | Antidepressants, analgesics and anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-08-18 | — | — | US | disclosed |
| US-4943571-A | ANALGESICS, ANTICONVULSANTS, ANTIDEPRESSANTS | HOECHST-ROUSSEL PHAMRACEUTICALS INC. (US) | 1990-07-24 | — | — | US | disclosed |
| US-4837227-A | ANALGESICS, ANTIDEPRESSANTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0148417-B1 | Analgesic dibenz[b,f]oxepins, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-01-20 | — | — | EP | disclosed |
| EP-0148417-A1 | Analgesic dibenz[b,f]oxepins, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-07-17 | — | — | EP | disclosed |
| US-4496582-A | Analgesic dibenz[b,f]oxepins | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0002508-B1 | AMINOALKYLTHIODIBENZOXEPINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148577-A1 | 1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | TNF, IL1B, IL1A | HPGD 141/4885L3MBTL1 1687/4885MAOB 1488/4885 |
| US-20110218192-A1 | Inhibitors Of Beta-Secretase | BACE1, BACE2, APP | HPGD 2870/4885L3MBTL1 4451/4885MAOB 681/4885 |
| US-20050130956-A1 | 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | TNF, IL1A, IL1B | HPGD 184/4885L3MBTL1 1630/4885MAOB 1462/4885 |
| US-20130317014-A1 | INHIBITORS OF BETA-SECRETASE | BACE1, BACE2, APP | HPGD 2870/4885L3MBTL1 4451/4885MAOB 681/4885 |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | HPGD 146/4885L3MBTL1 1949/4885MAOB 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.