SCHEMBL11577392

SCHEMBL11577392

C#CCN1CCN(C2Cc3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HRH4 Q9H3N8 1/20 0.41
HRH3 Q9Y5N1 1/20 0.41
MAOB P27338 5/20 0.38
DRD2 P14416 5/20 0.37
HRH1 P35367 4/20 0.37
DRD4 P21917 4/20 0.37
HTR2C P28335 3/20 0.37
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
TSHR P16473 1/20 0.37
NFKB1 P19838 1/20 0.37
CYP2C19 P33261 1/20 0.37
THPO P40225 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11574753 0.78 POLB (0.41) POLBGAAMAPTMAPK1SMN1; SMN2
SCHEMBL11578777 0.78 TP53 (0.46) POLBGAAMAPTMAPK1SMN1; SMN2
Hydrochloric Acid SCHEMBL11576667 0.78 POLB (0.40) POLBGAAMAPTMAPK1SMN1; SMN2
SCHEMBL11575385 0.76 ALDH1A1 (0.47) POLBGAAMAPTSMN1; SMN2HRH1
SCHEMBL11576214 0.75 MAPT (0.41) POLBGAAMAPTMAPK1SMN1; SMN2
Hydrochloric Acid SCHEMBL11576412 0.75 POLB (0.42) POLBGAAMAPTMAPK1SMN1; SMN2
SCHEMBL11578128 0.74 RAD52 (0.53) MAPTHRH4HRH3DRD2HRH1
SCHEMBL11574667 0.73 MAPT (0.49) POLBGAAMAPTMAPK1SMN1; SMN2
SCHEMBL11576209 0.73 DRD2 (0.55) MAPTHRH4HRH3DRD2HRH1
Hydrochloric Acid SCHEMBL11576513 0.73 RAD52 (0.53) MAPTHRH4HRH3DRD2HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4032525-A CNS DEPRESSANTS, NEUROLEPTICS HOFFMANN-LA ROCHE INC. (US) 1977-06-28 US claimed
US-4118572-A CNS DEPRESSANTS, NEUROLEPTIC AGENTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-10-03 US disclosed
US-4105664-A Dibenz[b,f]oxepin derivatives HOFFMANN-LA ROCHE INC. (US) 1978-08-08 US disclosed
US-4100173-A DEPRESSANTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-07-11 US disclosed
US-4091023-A ANTISCHIZOPHRENIA AGENTS, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-05-23 US disclosed
US-4032525-A CNS DEPRESSANTS, NEUROLEPTICS HOFFMANN-LA ROCHE INC. (US) 1977-06-28 US disclosed