Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | GHSR | Q92847 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.53 |
| ▸ | GABRP | O00591 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11581617 | 0.94 | TP53 (0.63) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11578684 | 0.91 | TP53 (0.57) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11577333 | 0.91 | TP53 (0.64) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11579759 | 0.90 | OPRK1 (0.72) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11579807 | 0.89 | TP53 (0.67) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11748770 | 0.89 | TP53 (0.62) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11577306 | 0.88 | OPRK1 (0.67) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11576567 | 0.88 | TP53 (0.56) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11578953 | 0.87 | OPRK1 (0.56) | TP53LMNAOPRK1KCNH2HTR1A | |
| SCHEMBL11579769 | 0.87 | TP53 (0.62) | TP53LMNAOPRK1KCNH2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4010154-A | Benzodiazepinones | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-03-01 | — | — | US | claimed |
| US-4079053-A | Benzodiazepine derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1978-03-14 | — | — | US | disclosed |
| US-4010154-A | Benzodiazepinones | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-03-01 | — | — | US | disclosed |
| US-3932637-A | 1-ALKYLSULFONYLALKYL-1,4-BENZODIAZEPINONES | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-01-13 | — | — | US | disclosed |