SCHEMBL11580693

SCHEMBL11580693

COc1ccc(Oc2cccc3c2C(=O)c2c(N)cccc2C3=O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNE2 O96020 1/20 0.52
CDK4 P11802 1/20 0.52
CCND1 P24385 1/20 0.52
CCNE1 P24864 1/20 0.52
CDK2 P24941 1/20 0.52
ADORA2A P29274 3/20 0.50
RAB9A P51151 3/20 0.46
NPC1 O15118 2/20 0.46
ATM Q13315 1/20 0.46
BACE1 P56817 1/20 0.46
EGFR P00533 1/20 0.46
PIM1 P11309 1/20 0.46
RPS6KA2 Q15349 1/20 0.45
ELANE P08246 2/20 0.45
GAPDH P04406 1/20 0.44
ALDH1A1 P00352 3/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11581493 0.96 ADORA2A (0.51) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL11581548 0.89 ADORA2A (0.50) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL11580911 0.87 ADORA2A (0.59) ADORA2ARAB9APIM1GAPDHALDH1A1
SCHEMBL21816994 0.85 CES2 (0.53) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL10811289 0.85 EGFR (0.61) ADORA2ARAB9AEGFRPIM1ELANE
SCHEMBL11580302 0.84 ADORA2A (0.49) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL11581660 0.84 ADORA2A (0.51) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL2302266 0.82 ADORA2A (0.61) ADORA2ARAB9APIM1GAPDHALDH1A1
SCHEMBL11583369 0.81 ADORA2A (0.51) ADORA2APIM1ALDH1A1MEN1KMT2A
SCHEMBL11580870 0.81 ADORA2A (0.47) CCNE2CDK4CCND1CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4126626-A DYES, POLYESTERS CIBA-GEIGY CORPORATION (US) 1978-11-21 US disclosed