SCHEMBL1158089

SCHEMBL1158089

CSCC[C@@H](C(=O)O)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.73
ALDH1A1 P00352 4/20 0.66
KDM4E B2RXH2 3/20 0.66
POLB P06746 3/20 0.66
TP53 P04637 1/20 0.66
GLA P06280 1/20 0.66
CYP3A4 P08684 1/20 0.66
CYP2D6 P10635 1/20 0.66
HPGD P15428 1/20 0.66
ALOX12 P18054 1/20 0.66
NFKB1 P19838 1/20 0.66
APEX1 P27695 1/20 0.66
HSD17B10 Q99714 1/20 0.66
ALOX15 P16050 1/20 0.64
GAA P10253 4/20 0.59
KMT2A Q03164 3/20 0.57
MEN1 O00255 2/20 0.57
SMN1; SMN2 Q16637 2/20 0.56
HIF1A Q16665 1/20 0.52
USP2 O75604 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30299427 1.00 MAPK1 (0.73) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL2271232 1.00 MAPK1 (0.73) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL2272378 1.00 MAPK1 (0.73) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL2888134 0.83 POLB (0.71) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL30165546 0.83 POLB (0.71) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL6896852 0.81 ALDH1A1 (0.79) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL6896845 0.81 ALDH1A1 (0.79) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL10617336 0.81 ALDH1A1 (0.73) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL133528 0.80 POLB (0.68) MAPK1ALDH1A1KDM4EPOLBTP53
SCHEMBL29783279 0.80 POLB (0.68) MAPK1ALDH1A1KDM4EPOLBTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7888417-B2 core or the layer includes a composition formed from a base polymer, a crosslink initiator, and at least one additive; additive has at least one carbon-oxygen-boron linkage, carbon in the linkage being a secondary or tertiary carbon; enhances coefficient of restitution and/or reduces compression of core ACUSHNET COMPANY (US) 2011-02-15 US disclosed
US-20080261722-A1 COMPOSITIONS FOR USE IN GOLF BALLS ACUSHNET COMPANY 2008-10-23 US disclosed
US-20080227567-A1 COMPOSITIONS FOR USE IN GOLF BALLS ACUSHNET COMPANY 2008-09-18 US disclosed
US-20080176678-A1 Compositions for Use in Golf Balls ACUSHNET COMPANY 2008-07-24 US disclosed
US-7361711-B2 Compositions for use in golf balls ACUSHNET COMPANY (US) 2008-04-22 US disclosed
US-7358309-B2 core or the layer includes a composition formed from a base polymer, a crosslink initiator, and at least one additive; additive has at least one carbon-oxygen-boron linkage, carbon in the linkage being a secondary or tertiary carbon; enhances coefficient of restitution and/or reduces compression of core ACUSHNET COMPANY (US) 2008-04-15 US disclosed
US-7358310-B2 Compositions for use in golf balls ACUSHNET COMPANY (US) 2008-04-15 US disclosed
US-7358308-B2 Compositions for use in golf balls ACUSHNET COMPANY (US) 2008-04-15 US disclosed
US-20060281586-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2006-12-14 US disclosed
US-20060281587-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2006-12-14 US disclosed
US-20050245652-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2005-11-03 US disclosed
US-20050245657-A1 Compositions for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2005-11-03 US disclosed