Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 11/20 | 0.77 |
| ▸ | GAA | P10253 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.59 |
| ▸ | SNCA | P37840 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | BCHE | P06276 | 2/20 | 0.59 |
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22960441 | 0.91 | NOX1 (0.65) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL22960495 | 0.91 | NOX1 (0.68) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL8156018 | 0.90 | NOX1 (0.62) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL2706291 | 0.88 | NOX1 (0.59) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL31094230 | 0.87 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL8608372 | 0.87 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL22960576 | 0.85 | NOX1 (0.70) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL22960468 | 0.85 | NOX1 (0.65) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL23954142 | 0.82 | NOX1 (0.66) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL9980103 | 0.82 | NOX1 (0.54) | NOX1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| US-10442779-B2 | Compositions and methods for treating Friedreich's ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2019-10-15 | — | — | US | disclosed |
| US-7332516-B2 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents | MERCK + CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-4115571-A | DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4077959-A | DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC | MEAD JOHNSON & COMPANY (US) | 1978-03-07 | — | — | US | disclosed |
| US-3946004-A | DIURETICS, MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1976-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442779-B2 | Compositions and methods for treating Friedreich's ataxia | ATXN10, ATXN2, ATXN2L | NOX1 3652/4885GAA 104/4885MAPT 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.