Sugi Predict

Sugi Predict / Compounds / SCHEMBL1158538

SCHEMBL1158538

SCHEMBL1158538

COCCCNc1nc(Nc2cc(C)ccn2)cc2cc[nH]c(=O)c12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KARS1 Q15046 4/20 0.41
▸ LMNA P02545 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ FER P16591 1/20 0.38
▸ ZAP70 P43403 2/20 0.37
▸ SYK P43405 3/20 0.36
▸ MAPT P10636 1/20 0.36
▸ TYK2 P29597 2/20 0.35
▸ BRD4 O60885 1/20 0.35
▸ ATAD2 Q6PL18 1/20 0.35
▸ MAP4K4 O95819 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ LCK P06239 1/20 0.34
▸ FYN P06241 1/20 0.34
▸ IGF1R P08069 1/20 0.34
▸ LTK P29376 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1158220 0.94 FER (0.39) KARS1FERZAP70SYKTYK2
SCHEMBL1158364 0.89 KARS1 (0.42) KARS1KDM4EFERZAP70SYK
SCHEMBL1158622 0.88 KARS1 (0.43) KARS1FERZAP70SYKTYK2
SCHEMBL1158330 0.87 KDM4E (0.43) KDM4EALDH1A1POLBFERZAP70
SCHEMBL12848848 0.87 FER (0.40) KARS1KDM4EFERZAP70SYK
SCHEMBL1158729 0.86 KARS1 (0.49) KARS1KDM4EALDH1A1FERZAP70
SCHEMBL1158652 0.85 FER (0.41) KARS1SMN1; SMN2ALDH1A1FERZAP70
SCHEMBL6524126 0.84 ATAD2 (0.48) KARS1FERZAP70SYKTYK2
SCHEMBL1158121 0.83 FER (0.38) KARS1FERZAP70SYKTYK2
SCHEMBL6525200 0.83 FER (0.38) KARS1FERZAP70SYKTYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2459556-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2012-06-06 — — EP claimed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US claimed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO claimed
EP-2459556-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2012-06-06 — — EP disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO disclosed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS SYK, BTK, LYN KARS1 2211/4885LMNA 3710/4885HTT 3244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.