Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.42 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116601 | 1.00 | GPR119 (0.42) | GPR119SETD7PARP1PARP2MET | |
| SCHEMBL116524 | 0.84 | GPR119 (0.41) | GPR119 | |
| SCHEMBL116110 | 0.83 | GPR119 (0.47) | GPR119SETD7 | |
| SCHEMBL113688 | 0.83 | GPR119 (0.47) | GPR119SETD7 | |
| SCHEMBL115588 | 0.77 | IDO1 (0.44) | GPR119 | |
| SCHEMBL3118258 | 0.76 | GPR119 (0.41) | GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL3103594 | 0.76 | GPR119 (0.41) | GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL3101945 | 0.76 | GPR119 (0.41) | GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL3103063 | 0.76 | GPR119 (0.41) | GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL3101956 | 0.76 | GPR119 (0.41) | GPR119SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |