Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 5/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | GPR4 | P46093 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115588 | 0.89 | IDO1 (0.44) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL116601 | 0.84 | GPR119 (0.42) | GPR119 | |
| SCHEMBL115872 | 0.84 | GPR119 (0.42) | GPR119 | |
| SCHEMBL115666 | 0.81 | GPR119 (0.44) | GPR119ACKR3PLK1CHRM2CHRM4 | |
| SCHEMBL14190954 | 0.77 | GPR4 (0.47) | GPR119ACKR3CHRM2CHRM4CHRM1 | |
| SCHEMBL23303996 | 0.77 | CHRM2 (0.46) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3708001 | 0.77 | HTR2A (0.52) | PLK1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6822757 | 0.76 | VEGFA (0.45) | ACKR3PLK1CHRM2CHRM4CHRM1 | |
| SCHEMBL116522 | 0.75 | CYP3A4 (0.46) | GPR119 | |
| SCHEMBL116523 | 0.75 | CYP3A4 (0.46) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |