Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5821426 | 0.88 | SLC22A6 (0.43) | TDP1SLC22A6LMNASMN1; SMN2MAPT | |
| Ammonia Solution, Strong SCHEMBL28654999 | 0.85 | TDP1 (0.46) | TDP1SLC22A6LMNASMN1; SMN2MAPT | |
| SCHEMBL1962382 | 0.79 | — | — | |
| SCHEMBL10565786 | 0.79 | — | — | |
| SCHEMBL17260751 | 0.79 | — | — | |
| SCHEMBL28802288 | 0.77 | ALDH1A1 (0.39) | TDP1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL5709315 | 0.77 | TDP1 (0.39) | TDP1SLC22A6LMNASMN1; SMN2MAPT | |
| SCHEMBL1405827 | 0.76 | — | — | |
| SCHEMBL13227957 | 0.76 | ALDH1A1 (0.48) | TDP1ALDH1A1 | |
| SCHEMBL16576 | 0.76 | CACNA2D1 (0.45) | TDP1ALDH1A1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782390-B2 | Amidine substituted β-lactam compounds, their preparation and use as antibacterial agents | AICURIS GMBH & CO. KG (DE) | 2017-10-10 | — | — | US | disclosed |
| US-20170100379-A1 | AMIDINE SUBSTITUTED BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS | AICURIS GMBH & CO. KG (DE) | 2017-04-13 | — | — | US | disclosed |
| US-9556165-B2 | Amidine substituted β-lactam compounds, their preparation and use as antibacterial agents | AICURIS GMBH & CO. KG (DE) | 2017-01-31 | — | — | US | disclosed |
| EP-2806873-B1 | AMIDINE SUBSTITUTED BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS | AICURIS GMBH & CO KG (DE) | 2016-06-15 | — | — | EP | disclosed |
| US-20150045340-A1 | AMIDINE SUBSTITUTED BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS | AICURIS GMBH & CO. KG (DE) | 2015-02-12 | — | — | US | disclosed |
| CN-104203237-A | Amidine-substituted beta-lactam compounds, their preparation and their use as antibacterial agents | AICURIS GMBH & CO KG | 2014-12-10 | — | — | CN | disclosed |
| US-4072660-A | FROM A 4-OXO-CARBOXYLIC ACID ESTER OR DELTA-ENOL-LACTONE AND STRONG BASE IN GLYCOL DIALKYL ETHER SOLVENT | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170100379-A1 | AMIDINE SUBSTITUTED BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS | AAAS, MGAM, PAM | TDP1 4542/4885ALDH1A1 4654/4885SLC22A6 2947/4885 |
| US-20150045340-A1 | AMIDINE SUBSTITUTED BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS | AAAS, MGAM, PAM | TDP1 4542/4885ALDH1A1 4654/4885SLC22A6 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.