Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.52 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6550216 | 0.90 | POLB (0.62) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL11596782 | 0.90 | LMNA (0.57) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL11712963 | 0.89 | POLB (0.61) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL11596689 | 0.88 | LMNA (0.56) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL11596906 | 0.87 | LMNA (0.55) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL11344085 | 0.87 | MAPT (0.53) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL18723228 | 0.86 | POLB (0.75) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL11531085 | 0.86 | LMNA (0.54) | POLBTDP1L3MBTL1MCL1LMNA | |
| SCHEMBL6550219 | 0.86 | POLB (0.60) | POLBTDP1L3MBTL1MAPTHTT | |
| SCHEMBL11597183 | 0.82 | LMNA (0.51) | POLBTDP1L3MBTL1MCL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125614-A | DIURETIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-11-14 | — | — | US | disclosed |
| US-4061761-A | Thiazolidine derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | disclosed |