Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.47 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11531085 | 0.89 | LMNA (0.54) | LMNAMAPTTP53MCL1POLB | |
| SCHEMBL11598628 | 0.87 | POLB (0.65) | LMNAMAPTTP53MCL1POLB | |
| SCHEMBL11596782 | 0.87 | LMNA (0.57) | LMNAMAPTTP53MCL1POLB | |
| SCHEMBL11344085 | 0.87 | MAPT (0.53) | LMNAMAPTTP53MCL1POLB | |
| SCHEMBL11596689 | 0.86 | LMNA (0.56) | LMNAMAPTTP53MCL1POLB | |
| SCHEMBL11345225 | 0.84 | LMNA (0.50) | LMNAMAPTTP53MCL1POLB | |
| SCHEMBL11597183 | 0.80 | LMNA (0.51) | LMNAMAPTTP53MCL1POLB | |
| SCHEMBL11595997 | 0.80 | PRMT1 (0.55) | LMNAMAPTTP53POLBTDP1 | |
| SCHEMBL11597826 | 0.78 | POLB (0.51) | LMNAMAPTPOLBTDP1ALDH1A1 | |
| SCHEMBL6550216 | 0.78 | POLB (0.62) | LMNAMAPTTP53MCL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125614-A | DIURETIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-11-14 | — | — | US | disclosed |
| US-4061761-A | Thiazolidine derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | disclosed |