Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.30 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.30 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.30 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropyl Alcohol SCHEMBL27837527 | 0.84 | — | — | |
| Lactic Acid SCHEMBL5247738 | 0.83 | TP53 (0.48) | TP53ALDH1A1CPA1 | |
| Propionic Acid SCHEMBL11599557 | 0.79 | FFAR3 (0.50) | TP53ALDH1A1HDAC1HDAC2TDP1 | |
| SCHEMBL11217135 | 0.79 | — | — | |
| Glycolic Acid SCHEMBL8987465 | 0.77 | ALDH1A1 (0.35) | TP53ALDH1A1HDAC1HDAC2TDP1 | |
| Propylene Glycol SCHEMBL19838949 | 0.77 | TDP1 (0.48) | ALDH1A1TDP1 | |
| SCHEMBL8072263 | 0.76 | FFAR1 (0.32) | ALDH1A1 | |
| SCHEMBL8086813 | 0.76 | GABRP (0.41) | HDAC1HDAC2 | |
| Maleic Acid SCHEMBL1535855 | 0.76 | TSHR (0.41) | TP53ALDH1A1 | |
| Fumaric Acid SCHEMBL1535857 | 0.76 | TSHR (0.41) | TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4095943-A | REACTING HALIDE SALT WITH THE ACID IN THE PRESENCE OF AN EPOXIDE COMPOUND | CIBA-GEIGY CORPORATION (US) | 1978-06-20 | — | — | US | disclosed |