Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3916333 | 0.71 | KDM4E (0.56) | KDM4ELMNARECQLKMT2AMEN1 | |
| SCHEMBL10256713 | 0.67 | KDM4E (0.50) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL5020848 | 0.66 | RECQL (0.73) | KDM4ELMNARECQLKMT2AMEN1 | |
| SCHEMBL11999964 | 0.65 | KDM4E (0.49) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL16663888 | 0.63 | RECQL (0.63) | KDM4ELMNARECQLKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL1520305 | 0.62 | MEN1 (0.93) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL18774372 | 0.61 | MEN1 (0.44) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8749841 | 0.60 | KDM4E (0.35) | KDM4ELMNARECQLKMT2AMEN1 | |
| Bromide SCHEMBL17075087 | 0.60 | KDM4E (0.49) | KDM4ELMNARECQLKMT2AMEN1 | |
| SCHEMBL26195059 | 0.58 | TDP1 (0.40) | KMT2AMEN1ALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4108668-A | Light-sensitive silver halide photographic materials | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1978-08-22 | — | — | US | disclosed |