Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11002073 | 0.72 | KMT2A (0.39) | KDM4EKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10033887 | 0.67 | ALDH1A1 (0.47) | LMNAKMT2AALDH1A1MAPTGAA | |
| Hydrochloric Acid SCHEMBL2314704 | 0.66 | KMT2A (0.53) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11210593 | 0.63 | RECQL (0.71) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL8120684 | 0.63 | KMT2A (0.54) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| Bromide SCHEMBL3888322 | 0.62 | KMT2A (0.60) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL5020848 | 0.61 | RECQL (0.73) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11435838 | 0.61 | ATM (0.66) | KDM4ELMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL29139842 | 0.59 | CA1 (0.41) | MAPT | |
| SCHEMBL11001192 | 0.59 | RAB9A (0.39) | KDM4ELMNAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763771-A1 | Silver halide photographic elements containing aryl hydrazines | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-03-19 | — | — | EP | disclosed |