Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MMP2 | P08253 | 1/20 | 0.65 |
| ▸ | MMP9 | P14780 | 1/20 | 0.65 |
| ▸ | MMP8 | P22894 | 1/20 | 0.65 |
| ▸ | MMP13 | P45452 | 1/20 | 0.65 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.59 |
| ▸ | MPL | P40238 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.51 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10826401 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL7602620 | 0.94 | KDM4E (0.70) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL28930292 | 0.92 | KDM4E (0.68) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL1665158 | 0.89 | KDM4E (0.65) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL7943525 | 0.88 | KDM4E (0.63) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL3200579 | 0.88 | CHEK2 (0.69) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL1663947 | 0.88 | KDM4E (0.63) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL20982511 | 0.87 | MMP2 (0.78) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL20982594 | 0.86 | NR4A2 (0.77) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL12471017 | 0.86 | KDM4E (0.61) | KDM4EALDH1A1HPGDKMT2AMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-03-30 | — | — | US | disclosed |
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-03-30 | — | — | US | disclosed |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-05-23 | — | — | US | disclosed |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-05-23 | — | — | US | disclosed |
| US-4067804-A | POLYOXADIAZOLE RESIN | THE FURUKAWA ELECTRIC COMPANY, LIMITED (JA) | 1978-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | HNRNPH1, HNRNPH3, HNRNPUL2 | KDM4E 1792/4885ALDH1A1 3412/4885HPGD 4664/4885 |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | HNRNPH1, HNRNPH3, HNRNPUL2 | KDM4E 1792/4885ALDH1A1 3412/4885HPGD 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.