Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | GABRP | O00591 | 2/20 | 0.57 |
| ▸ | GABRD | O14764 | 2/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.57 |
| ▸ | GABRE | P78334 | 2/20 | 0.57 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.57 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL333291 | 0.91 | MAPT (0.67) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| SCHEMBL31384417 | 0.91 | MAPT (0.67) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| Ammonia Solution, Strong SCHEMBL28210514 | 0.90 | MAPT (0.65) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| Ethane SCHEMBL11534058 | 0.90 | MAPT (0.65) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| SCHEMBL8959210 | 0.82 | ALDH1A1 (0.67) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| SCHEMBL13603806 | 0.80 | MAPT (0.60) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| SCHEMBL11636235 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1GAALMNA | |
| SCHEMBL27611956 | 0.80 | MAPT (0.72) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| SCHEMBL9853488 | 0.80 | MAPT (0.63) | SMN1; SMN2MAPTALDH1A1GAAKDM4E | |
| SCHEMBL13263480 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4072710-A | FROM SILYL ESTER AND THIONYL CHLORIDE | PALOMO COLL A L | 1978-02-07 | — | — | US | disclosed |