Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969326 | 1.00 | PSEN1 (0.42) | PSEN1ALOX5PTPN1GSTO1MEN1 | |
| SCHEMBL11601582 | 1.00 | PSEN1 (0.42) | PSEN1ALOX5PTPN1GSTO1MEN1 | |
| SCHEMBL10752967 | 0.89 | ALOX5 (0.46) | PSEN1ALOX5PTPN1GSTO1MEN1 | |
| SCHEMBL10535178 | 0.89 | PSEN1 (0.40) | PSEN1ALOX5GSTO1MEN1KMT2A | |
| SCHEMBL10756760 | 0.88 | KCNA3 (0.35) | PSEN1ALOX5PTPN1PPARG | |
| SCHEMBL29670864 | 0.85 | PSEN1 (0.44) | PSEN1ALOX5PTPN1GSTO1MEN1 | |
| SCHEMBL7839568 | 0.85 | PSEN1 (0.42) | PSEN1ALOX5PTPN1GSTO1MEN1 | |
| SCHEMBL11440558 | 0.85 | PSEN1 (0.44) | PSEN1ALOX5PTPN1GSTO1MEN1 | |
| SCHEMBL7843126 | 0.85 | PSEN1 (0.44) | PSEN1ALOX5PTPN1GSTO1MEN1 | |
| SCHEMBL11440561 | 0.85 | PSEN1 (0.44) | PSEN1ALOX5PTPN1GSTO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4110346-A | Tetramethyl chromanyl pentane derivatives | HOFFMANN-LA ROCHE INC. (US) | 1978-08-29 | — | — | US | disclosed |
| US-4088662-A | Optically active amides and process for producing the same | HOFFMANN-LA ROCHE INC. (US) | 1978-05-09 | — | — | US | disclosed |
| US-4086249-A | Tetramethyl chromanyl pentane amide | HOFFMANN-LA ROCHE INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4076739-A | Synthesis of vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1978-02-28 | — | — | US | disclosed |
| US-4016178-A | Synthesis of vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1977-04-05 | — | — | US | disclosed |