Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.35 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846560 | 0.79 | HSP90AB1 (0.53) | CYP3A4MAPK1PIK3CALMNAHTT | |
| SCHEMBL7300776 | 0.76 | TSHR (0.52) | CYP3A4MAPK1PIK3CAHTTSMN1; SMN2 | |
| SCHEMBL4946050 | 0.75 | MEN1 (0.54) | HTTRAB9AMEN1KMT2ASHBG | |
| SCHEMBL30506530 | 0.75 | MEN1 (0.54) | HTTRAB9AMEN1KMT2ASHBG | |
| SCHEMBL9717586 | 0.74 | MAPK1 (0.40) | CYP3A4MAPK1PIK3CALMNAHTT | |
| SCHEMBL12231322 | 0.74 | GRM2 (0.38) | PIK3CA | |
| SCHEMBL9717543 | 0.74 | HTT (0.53) | HTTMEN1KMT2A | |
| SCHEMBL11603757 | 0.73 | CYP2C9 (0.58) | LMNAHTTKDM4EMEN1KMT2A | |
| SCHEMBL31610902 | 0.73 | HSP90AB1 (0.65) | CYP3A4LMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL9734150 | 0.73 | KMT2A (0.42) | CYP3A4MAPK1PIK3CALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4070539-A | DIURETICS, SALURETICS | MERCK & CO., INC. (US) | 1978-01-24 | — | — | US | disclosed |