Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | SHBG | P04278 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15700811 | 0.86 | HSP90AB1 (0.52) | HSP90AB1POLBHMGCRALDH1A1CYP3A4 | |
| SCHEMBL481119 | 0.86 | HSP90AB1 (0.52) | HSP90AB1POLBHMGCRALDH1A1CYP3A4 | |
| SCHEMBL30209765 | 0.86 | HSP90AB1 (0.52) | HSP90AB1POLBHMGCRALDH1A1CYP3A4 | |
| SCHEMBL7300776 | 0.85 | TSHR (0.52) | HSP90AB1ALDH1A1CYP3A4MAPK1PIK3CA | |
| SCHEMBL27787230 | 0.83 | HSP90AB1 (0.49) | HSP90AB1POLBHMGCRALDH1A1CYP3A4 | |
| SCHEMBL10769427 | 0.82 | HSP90AB1 (0.47) | HSP90AB1POLBHMGCRALDH1A1CYP3A4 | |
| SCHEMBL9717543 | 0.82 | HTT (0.53) | ALDH1A1MEN1KMT2AHTTMAPT | |
| SCHEMBL28385050 | 0.82 | HSP90AB1 (0.46) | HSP90AB1POLBHMGCRALDH1A1CYP3A4 | |
| SCHEMBL11601698 | 0.79 | CYP3A4 (0.38) | POLBCYP3A4MAPK1PIK3CAMEN1 | |
| SCHEMBL10356111 | 0.79 | HTT (0.58) | ALDH1A1MEN1KMT2AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189596-A1 | Benzofuran and benzothiophene derivatives | SHIONOGI & CO., LTD. (JP) | 1986-08-06 | — | — | EP | disclosed |