Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.47 |
| ▸ | THRB | P10828 | 6/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603708 | 0.93 | HTT (0.58) | HTTHSD17B3THRBTHRAMAPT | |
| SCHEMBL10356111 | 0.93 | HTT (0.58) | HTTHSD17B3THRBTHRAMAPT | |
| SCHEMBL7300776 | 0.89 | TSHR (0.52) | HTTHSD17B3THRBTHRAALDH1A1 | |
| SCHEMBL22500456 | 0.88 | HTT (0.51) | HTTHSD17B3THRBTHRAMAPT | |
| SCHEMBL22500510 | 0.83 | HTT (0.58) | HTTHSD17B3THRBTHRAMAPT | |
| SCHEMBL10846560 | 0.82 | HSP90AB1 (0.53) | HTTTHRBTHRAMAPTMEN1 | |
| SCHEMBL9717586 | 0.80 | MAPK1 (0.40) | HTTTHRBTHRAMAPTMEN1 | |
| SCHEMBL22317250 | 0.79 | THRB (0.56) | HTTTHRBTHRAMAPTMEN1 | |
| SCHEMBL9734150 | 0.79 | KMT2A (0.42) | HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL10350961 | 0.79 | HTT (0.56) | HTTHSD17B3MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240256-B1 | COMPOUNDS USEFUL IN TREATING SICKLE CELL ANEMIA | MERCK & CO. INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4731473-A | Compounds useful in treating sickle cell anemia | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4731381-A | Method of treating a person for sickle cell anemia | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4699926-A | Compounds useful in treating sickle cell anemia | MERCK & CO., INC. (US) | 1987-10-13 | — | — | US | disclosed |
| EP-0240256-A2 | Compounds useful in treating sickle cell anemia | MERCK & CO. INC. (US) | 1987-10-07 | — | — | EP | disclosed |
| US-4070539-A | DIURETICS, SALURETICS | MERCK & CO., INC. (US) | 1978-01-24 | — | — | US | disclosed |