Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.80 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.80 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.80 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.76 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11712840 | 0.91 | OPRM1 (0.82) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Etoxeridine SCHEMBL908077 | 0.89 | OPRM1 (0.71) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL11712071 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL11708747 | 0.88 | KCNA3 (0.80) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL11599945 | 0.88 | OPRM1 (0.78) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Hydrochloric Acid SCHEMBL11603600 | 0.87 | OPRM1 (0.79) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Pheneridine SCHEMBL1922392 | 0.87 | KCNA3 (0.86) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Morpheridine SCHEMBL908537 | 0.87 | OPRM1 (0.76) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL25431 | 0.86 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Carperidine SCHEMBL2107753 | 0.86 | OPRM1 (0.74) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4072686-A | ANTIDIARRHEAL | G. D. SEARLE & CO. (US) | 1978-02-07 | — | — | US | disclosed |
| US-4066654-A | 1-TRIARYLALKYL-4-PHENYL-4-PIPERIDINE CARBOXYLIC ACIDS AND DERIVATIVES | G. D. SEARLE & CO. (US) | 1978-01-03 | — | — | US | disclosed |