Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.79 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | EPRS1 | P07814 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788463 | 1.00 | DHODH (0.80) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL29536364 | 0.89 | DHODH (1.00) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL2467110 | 0.89 | DHODH (1.00) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| Cinchophen SCHEMBL7588217 | 0.89 | KDM4E (1.00) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| Cinchophen SCHEMBL25519 | 0.89 | KDM4E (1.00) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| Cinchophen SCHEMBL29376617 | 0.89 | KDM4E (1.00) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL10865568 | 0.88 | DHODH (0.62) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| Cinchophen SCHEMBL10757475 | 0.87 | KDM4E (0.97) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| Cinchophen SCHEMBL4464779 | 0.87 | KDM4E (0.97) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| Cinchophen SCHEMBL4805149 | 0.87 | KDM4E (0.97) | DHODHKDM4ELMNASMN1; SMN2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103804419-B | 2-(4-bromophenyl) quinoline-4-formate complex and its preparation method and application | SHANDONG UNIVERSITY OF TECHNOLOGY (CN) | 2016-01-06 | — | — | CN | claimed |
| CN-103804419-A | 2-(4-bromophenyl) quinoline-4-formic acid complex and preparation method and application thereof | UNIV SHANDONG TECHNOLOGY | 2014-05-21 | — | — | CN | claimed |
| WO-2010020672-A1 | NOVEL PHENYL-QUINOLINE-CARBOXYLIC ACID PYRIDINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-02-25 | — | — | WO | claimed |
| CN-111574530-B | ACC inhibitor and medical application thereof | 徐州医科大学 | 2022-07-26 | — | — | CN | disclosed |
| CN-111574530-A | ACC inhibitor and medical application thereof | 徐州医科大学 | 2020-08-25 | — | — | CN | disclosed |
| WO-2017189958-A1 | PHENYLQUINOLINE COMPOSITIONS FOR TREATMENT OF OCULAR DISORDERS AND CONDITIONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2017-11-02 | — | — | WO | disclosed |
| US-9663488-B2 | Metalloenzyme inhibitor compounds | VIAMET PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663488-B2 | Metalloenzyme inhibitor compounds | VIAMET PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| CN-103804419-B | 2-(4-bromophenyl) quinoline-4-formate complex and its preparation method and application | SHANDONG UNIVERSITY OF TECHNOLOGY (CN) | 2016-01-06 | — | — | CN | disclosed |
| CN-103804419-B | 2-(4-bromophenyl) quinoline-4-formate complex and its preparation method and application | SHANDONG UNIVERSITY OF TECHNOLOGY (CN) | 2016-01-06 | — | — | CN | disclosed |
| CN-103804419-B | 2-(4-bromophenyl) quinoline-4-formate complex and its preparation method and application | SHANDONG UNIVERSITY OF TECHNOLOGY (CN) | 2016-01-06 | — | — | CN | disclosed |
| WO-2010020672-A1 | NOVEL PHENYL-QUINOLINE-CARBOXYLIC ACID PYRIDINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-02-25 | — | — | WO | disclosed |
| WO-2006034512-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |
| WO-2006034491-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |
| CN-85106626-A | The preparation of 4-amino-2-phenyl-quinoline | — | 1987-03-25 | — | — | CN | disclosed |
| EP-0168812-A1 | 4-Amino-2-phenyl quinolines, methods and intermediates for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-01-22 | — | — | EP | disclosed |
| US-4560692-A | ANTICONVULSANTS OR ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1985-12-24 | — | — | US | disclosed |