Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.66 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413192 | 0.95 | PTGS2 (0.72) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL4404145 | 0.94 | PTGS2 (0.75) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL4410750 | 0.94 | PTGS2 (0.75) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL4266887 | 0.94 | PTGS2 (0.75) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL4273970 | 0.94 | PTGS2 (0.75) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL29515347 | 0.90 | MTNR1A (0.61) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL7751 | 0.90 | MTNR1A (0.61) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL12470556 | 0.86 | MTNR1A (0.61) | PTGS2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL13668910 | 0.83 | MTNR1A (0.61) | PTGS2MTNR1AMTNR1BALDH1A1POLB | |
| SCHEMBL8150310 | 0.82 | PTGS2 (0.67) | PTGS2ALDH1A1LMNACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012109527-A2 | CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-08-16 | — | — | WO | disclosed |
| US-4086240-A | 1-Thiazolyl-5-phenoxy and phenylthioalkanoyloxyimidazolidinones | VELSICOL CHEMICAL CORPORATION (US) | 1978-04-25 | — | — | US | disclosed |
| US-4053480-A | 1-THIADIAZOLYL-5-PHENOXY- AND PHENYLTHIOALKANOYLOXY IMIDAZOLIDINONES | VELSICOL CHEMICAL CORPORATION (US) | 1977-10-11 | — | — | US | disclosed |