Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.71 |
| ▸ | DRD3 | P35462 | 6/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | CCR1 | P32246 | 3/20 | 0.64 |
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | DRD1 | P21728 | 4/20 | 0.64 |
| ▸ | DRD5 | P21918 | 4/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.64 |
| ▸ | HTR2A | P28223 | 4/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.64 |
| ▸ | HTR7 | P34969 | 4/20 | 0.64 |
| ▸ | HRH1 | P35367 | 4/20 | 0.64 |
| ▸ | HTR2B | P41595 | 4/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.60 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11604246 | 0.92 | DRD2 (0.65) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL11605869 | 0.89 | CCR1 (0.69) | DRD2CCR1OPRM1 | |
| SCHEMBL11301741 | 0.84 | DRD2 (0.70) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL904905 | 0.83 | DRD2 (0.83) | DRD2DRD3SIGMAR1LMNACCR1 | |
| Hydroxyhaloperidol SCHEMBL4540106 | 0.83 | DRD2 (1.00) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL11602715 | 0.81 | OPRL1 (0.70) | DRD2CCR1OPRM1 | |
| SCHEMBL7455049 | 0.81 | CCR1 (0.62) | DRD2CCR1ADRA1A | |
| SCHEMBL10698888 | 0.81 | DRD2 (0.79) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL9105624 | 0.78 | CCR1 (1.00) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL4060617 | 0.78 | DRD2 (1.00) | DRD2DRD3SIGMAR1LMNACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082755-A | NEUROLEPTIC | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-04-04 | — | — | US | disclosed |