Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067533 | 0.89 | P2RX7 (0.67) | P2RX7HDAC6MEN1KMT2AHDAC3 | |
| SCHEMBL10131890 | 0.77 | P2RX7 (0.50) | P2RX7HDAC6MEN1KMT2AHDAC3 | |
| SCHEMBL9080180 | 0.77 | HDAC6 (0.54) | P2RX7HDAC6MEN1KMT2AHDAC3 | |
| SCHEMBL9949147 | 0.74 | P2RX7 (0.56) | P2RX7HDAC6MEN1KMT2AHDAC3 | |
| SCHEMBL4715282 | 0.73 | EPHX2 (0.64) | P2RX7MEN1KMT2AEPHX2ALDH1A1 | |
| SCHEMBL18088397 | 0.73 | HDAC6 (0.61) | P2RX7HDAC6MEN1KMT2AHDAC3 | |
| Hydrochloric Acid SCHEMBL1677932 | 0.72 | EPHX2 (0.62) | P2RX7MEN1KMT2AEPHX2ALDH1A1 | |
| SCHEMBL18085885 | 0.70 | HDAC6 (0.57) | P2RX7HDAC6MEN1KMT2AHDAC3 | |
| SCHEMBL25447653 | 0.69 | P2RX7 (1.00) | P2RX7MEN1KMT2AEPHX2ALDH1A1 | |
| SCHEMBL23023053 | 0.68 | EPHX2 (0.53) | P2RX7MEN1KMT2AEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459548-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012800-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-02-03 | — | — | WO | disclosed |