Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067533 | 0.86 | P2RX7 (0.67) | HDAC6P2RX7MEN1KMT2AHDAC3 | |
| SCHEMBL15008930 | 0.79 | CNR2 (0.54) | HDAC6MEN1KMT2AEPHX2LTA4H | |
| SCHEMBL18088397 | 0.77 | HDAC6 (0.61) | HDAC6P2RX7MEN1KMT2AHDAC3 | |
| SCHEMBL1160892 | 0.77 | P2RX7 (0.55) | HDAC6P2RX7MEN1KMT2AHDAC3 | |
| SCHEMBL8497858 | 0.76 | KDM4E (0.67) | MEN1KMT2AEPHX2LTA4HKDM4E | |
| SCHEMBL7756966 | 0.74 | KDM4E (0.70) | MEN1KMT2AEPHX2LTA4HKDM4E | |
| SCHEMBL18085885 | 0.74 | HDAC6 (0.57) | HDAC6P2RX7MEN1KMT2AHDAC3 | |
| Hydrochloric Acid SCHEMBL9079843 | 0.72 | KDM4E (0.68) | MEN1KMT2AEPHX2LTA4HKDM4E | |
| SCHEMBL18423583 | 0.72 | HDAC6 (0.70) | HDAC6P2RX7MEN1KMT2AHDAC3 | |
| SCHEMBL10131890 | 0.72 | P2RX7 (0.50) | HDAC6P2RX7MEN1KMT2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |