Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161436 | 0.81 | HTT (0.42) | MEN1KMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL4063142 | 0.79 | SMN1; SMN2 (0.50) | HPGDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1161490 | 0.79 | ERCC5 (0.43) | MEN1KMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL1161451 | 0.78 | FEN1 (0.42) | SLC2A1NPC1RAB9ASMN1; SMN2PARP1 | |
| SCHEMBL6930611 | 0.77 | RAB9A (0.48) | HPGDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1161630 | 0.77 | NQO2 (0.48) | HPGDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6930649 | 0.71 | TNKS (0.59) | KDM4EPARP1 | |
| SCHEMBL30186048 | 0.71 | TNKS (0.59) | KDM4EPARP1 | |
| SCHEMBL7504985 | 0.71 | TP53 (0.44) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2767091 | 0.70 | ALDH1A1 (0.47) | HPGDMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |