Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 8/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11615214 | 0.89 | RAB9A (0.52) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL11610881 | 0.89 | NPC1 (0.59) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL11612558 | 0.87 | NPC1 (0.57) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL11612906 | 0.86 | KDM4E (0.57) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL11612590 | 0.86 | KDM4E (0.57) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL11613419 | 0.83 | KDM4E (0.43) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL11613411 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL11614072 | 0.78 | RAB9A (0.47) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E | |
| SCHEMBL25259064 | 0.78 | ALDH1A1 (0.43) | NPC1RAB9AKDM4ECYP11B1CYP11B2 | |
| SCHEMBL11614228 | 0.77 | RAB9A (0.52) | SMN1; SMN2NPC1HSD17B10RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4066570-A | OPTICAL CELLS, NEMATIC MIXTURES, LIQUID CRYSTALS | HOFFMAN-LA ROCHE INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-3997536-A | LIQUID CRYSTALS | HOFFMANN-LA ROCHE INC. (US) | 1976-12-14 | — | — | US | disclosed |