Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MELK | Q14680 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23554874 | 0.80 | CCR1 (0.48) | HDAC1HDAC6HDAC5PDE10ACTSA | |
| SCHEMBL29550107 | 0.80 | CCR1 (0.48) | HDAC1HDAC6HDAC5PDE10ACTSA | |
| SCHEMBL10271357 | 0.80 | HDAC1 (0.36) | PDE3BPDE3AIMPDH2HDAC1HDAC6 | |
| SCHEMBL14911919 | 0.78 | PDE10A (0.38) | HDAC1HDAC6HDAC5PDE10ACTSA | |
| SCHEMBL28022103 | 0.74 | KCNH2 (0.42) | HDAC1PDE10ANPC1ALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL17395656 | 0.73 | CYSLTR1 (0.50) | PDE10AKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL498405 | 0.72 | CYSLTR1 (0.53) | PDE10A | |
| SCHEMBL29353900 | 0.72 | CYSLTR1 (0.53) | PDE10A | |
| SCHEMBL3064494 | 0.72 | IMPDH2 (0.42) | PDE3BPDE3AIMPDH2CTSAMALT1 | |
| SCHEMBL30695314 | 0.72 | IMPDH2 (0.42) | PDE3BPDE3AIMPDH2CTSAMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |
| US-5273980-A | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-12-28 | — | — | US | disclosed |
| EP-0535924-A1 | (Bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |