Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11740106 | 0.87 | GPR84 (0.54) | GPR84FFAR4FFAR1ACE2FAAH | |
| SCHEMBL30882121 | 0.82 | GPR84 (0.61) | GPR84FFAR4FFAR1ACE2 | |
| SCHEMBL544052 | 0.82 | GPR84 (0.61) | GPR84FFAR4FFAR1ACE2 | |
| SCHEMBL7550732 | 0.81 | FFAR4 (0.77) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL11615881 | 0.81 | FFAR4 (0.77) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL11615905 | 0.81 | FFAR4 (0.77) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL11618654 | 0.81 | FFAR4 (0.77) | GPR84FFAR4FFAR1FAAH | |
| SCHEMBL11616080 | 0.81 | ACE2 (0.57) | GPR84FFAR4FFAR1ACE2FAAH | |
| SCHEMBL23930717 | 0.80 | GPR84 (0.64) | GPR84FFAR4FFAR1ACE2 | |
| SCHEMBL3423500 | 0.80 | GPR84 (0.64) | GPR84FFAR4FFAR1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4097504-A | 11,12-Secoprostaglandins | MERCK & CO., INC. (US) | 1978-06-27 | — | — | US | disclosed |
| US-4092356-A | 11,12-Secoprostaglandins | MERCK & CO., INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4066692-A | 11,12-SECOPROSTAGLANDINS | MERCK & CO., INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-4059601-A | VASODILATION, HYPOTENSIVE, ANTITHROMBOSIS | MERCK & CO., INC. (US) | 1977-11-22 | — | — | US | disclosed |
| US-4059602-A | HYPOTENSIVE, VASODILATION, ANTITHROMBOSIS | MERCK & CO., INC. (US) | 1977-11-22 | — | — | US | disclosed |
| US-3991087-A | RENAL VASODILATORS, HYPOTENSIVE AGENTS, ANTITHROMBOTICS | MERCK & CO., INC. (US) | 1976-11-09 | — | — | US | disclosed |