Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Sulisobenzone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.90 |
| ▸ | MAPT | P10636 | 6/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.90 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulisobenzone SCHEMBL16330 | 0.95 | LMNA (1.00) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL9474717 | 0.95 | LMNA (1.00) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL167868 | 0.95 | LMNA (1.00) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL29360128 | 0.95 | LMNA (1.00) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL11277589 | 0.94 | LMNA (0.97) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL10491705 | 0.94 | LMNA (0.97) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL11142507 | 0.94 | LMNA (0.97) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL22712408 | 0.94 | LMNA (0.97) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL6295950 | 0.94 | LMNA (0.97) | LMNAMAPTKMT2AALDH1A1HPGD | |
| Sulisobenzone SCHEMBL10723301 | 0.94 | LMNA (0.97) | LMNAMAPTKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4131463-A | Electric recording process of images using electron sensitive layer containing trivalent cobalt complex and compound having conjugated π bond system | FUJI PHOTO FILM CO., LTD. (JP) | 1978-12-26 | — | — | US | disclosed |