SCHEMBL1161891

SCHEMBL1161891

CNCC(NC(=O)OCc1ccccc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CTSK P43235 6/20 0.56
CTSS P25774 4/20 0.55
CTSL P07711 3/20 0.55
CTSB P07858 3/20 0.55
PPARA Q07869 3/20 0.55
ALDH1A1 P00352 1/20 0.54
ALOX15 P16050 1/20 0.54
PPARG P37231 1/20 0.54
TACR1 P25103 2/20 0.53
KYNU Q16719 1/20 0.53
CTRB1 P17538 2/20 0.52
ATM Q13315 1/20 0.52
IDO1 P14902 1/20 0.52
TDO2 P48775 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13410408 1.00 CTSK (0.56) CTSKCTSSCTSLCTSBPPARA
SCHEMBL12873775 1.00 CTSK (0.56) CTSKCTSSCTSLCTSBPPARA
Hydrochloric Acid SCHEMBL1161839 0.99 CTSK (0.55) CTSKCTSSCTSLCTSBPPARA
SCHEMBL6498057 0.90 KYNU (0.62) CTSKCTSSCTSLCTSBALDH1A1
SCHEMBL3249670 0.90 KYNU (0.62) CTSKCTSSCTSLCTSBALDH1A1
SCHEMBL27649726 0.88 CTSK (0.54) CTSKCTSSCTSLCTSBPPARA
SCHEMBL27649725 0.88 CTSK (0.54) CTSKCTSSCTSLCTSBPPARA
SCHEMBL6200569 0.88 CTSK (0.51) CTSKCTSSCTSLCTSBPPARA
SCHEMBL7329157 0.87 CTSK (0.58) CTSKCTSSCTSLCTSBPPARA
SCHEMBL1191975 0.87 CTSK (0.58) CTSKCTSSCTSLCTSBPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2499148-A2 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS Polyphor Ag (CH) 2012-09-19 EP disclosed
EP-2462147-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS Polyphor Ag (CH) 2012-06-13 EP disclosed
WO-2011014973-A2 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2011-02-10 WO disclosed
WO-2011015241-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2011-02-10 WO disclosed