Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 18/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | DRD3 | P35462 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Apovincamine SCHEMBL11619190 | 0.99 | PDE1A (0.71) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL11619374 | 0.99 | PDE1A (0.71) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL29421625 | 0.92 | PDE1A (0.85) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL10574604 | 0.92 | PDE1A (0.85) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL10571224 | 0.92 | PDE1A (0.85) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL194507 | 0.92 | PDE1A (0.85) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL11621216 | 0.91 | PDE1A (0.69) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL11619316 | 0.89 | PDE1A (0.77) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL11621460 | 0.89 | PDE1A (0.79) | PDE1AMEN1LMNAKMT2AHIF1A | |
| Apovincamine SCHEMBL11619109 | 0.86 | PDE1A (0.72) | PDE1AMEN1LMNAKMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4122179-A | VASODILATORS | Mora, Enrico Corvi (IT) | 1978-10-24 | — | — | US | claimed |
| US-4122179-A | VASODILATORS | Mora, Enrico Corvi (IT) | 1978-10-24 | — | — | US | disclosed |