Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | RORB | Q92753 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584622 | 0.84 | CYP1A2 (0.58) | KDRCYP1A2LMNAKMT2AMEN1 | |
| SCHEMBL1769732 | 0.79 | JAK2 (0.62) | NOTUMNTRK1JAK2RETPDGFRB | |
| SCHEMBL10966762 | 0.78 | LMNA (0.61) | NOTUMNTRK1JAK2RETPDGFRB | |
| Hydrochloric Acid SCHEMBL30367906 | 0.76 | LMNA (0.59) | NOTUMNTRK1JAK2RETPDGFRB | |
| SCHEMBL11622285 | 0.73 | KDR (0.68) | NOTUMNTRK1JAK2RETPDGFRB | |
| SCHEMBL4048920 | 0.73 | CYP1A2 (0.62) | NOTUMCYP1A2LMNAKMT2AMEN1 | |
| SCHEMBL11742209 | 0.73 | CYP1A2 (0.56) | KDRCYP1A2LMNAKMT2AMEN1 | |
| SCHEMBL481916 | 0.72 | LMNA (0.67) | NOTUMKDRCYP1A2LMNAKMT2A | |
| SCHEMBL11628056 | 0.72 | ADORA2A (0.44) | NOTUMRORBHPGD | |
| Bromide SCHEMBL11739258 | 0.72 | CYP1A2 (0.61) | NOTUMCYP1A2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4112095-A | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1978-09-05 | — | — | US | disclosed |