Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11623894 | 1.00 | LMNA (0.51) | LMNAHIF1ACYP2D6OPRM1NPSR1 | |
| Hydrochloric Acid SCHEMBL11626176 | 0.81 | LMNA (0.56) | LMNAHIF1ACYP2D6OPRM1NPSR1 | |
| Hydrochloric Acid SCHEMBL11626178 | 0.81 | LMNA (0.56) | LMNAHIF1ACYP2D6OPRM1NPSR1 | |
| Clocinizine SCHEMBL2193158 | 0.77 | LMNA (0.84) | LMNAHIF1ACYP2D6OPRM1NPSR1 | |
| Clocinizine SCHEMBL30363 | 0.77 | LMNA (0.84) | LMNAHIF1ACYP2D6OPRM1NPSR1 | |
| SCHEMBL11624816 | 0.77 | HRH3 (0.55) | CYP2D6OPRM1GAAOPRD1OPRK1 | |
| Clocinizine SCHEMBL4416376 | 0.76 | LMNA (0.82) | LMNAHIF1ACYP2D6OPRM1NPSR1 | |
| Clocinizine SCHEMBL6659465 | 0.76 | LMNA (0.82) | LMNAHIF1ACYP2D6OPRM1NPSR1 | |
| SCHEMBL11627583 | 0.75 | HRH3 (0.53) | CYP2D6GAAOPRK1CHRM2ADRA2A | |
| SCHEMBL11625461 | 0.74 | HRH3 (0.58) | CYP2D6OPRM1OPRD1OPRK1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125612-A | N-1-(p-Biphenylalkyl)piperazines and their use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1978-11-14 | — | — | US | disclosed |