Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430966 | 0.95 | HTR6 (0.46) | HTR6SIGMAR1HTR7MAPTMTNR1A | |
| SCHEMBL8952468 | 0.89 | HTR6 (0.54) | HTR6SIGMAR1HTR7MTNR1AMTNR1B | |
| SCHEMBL3868123 | 0.88 | HTR6 (0.53) | HTR6SIGMAR1HTR7MAPTMTNR1A | |
| SCHEMBL3874874 | 0.88 | HTR6 (0.53) | HTR6SIGMAR1HTR7MAPTMTNR1A | |
| SCHEMBL31121639 | 0.84 | HTR6 (0.56) | HTR6SIGMAR1HTR7MTNR1AMTNR1B | |
| SCHEMBL2338975 | 0.84 | HTR6 (0.56) | HTR6SIGMAR1HTR7MTNR1AMTNR1B | |
| SCHEMBL20430497 | 0.81 | HTR6 (0.47) | HTR6SIGMAR1HTR7POLB | |
| SCHEMBL16340383 | 0.81 | HTR6 (0.47) | HTR6SIGMAR1HTR7MAPT | |
| SCHEMBL6683873 | 0.81 | HTR6 (0.51) | HTR6SIGMAR1HTR7 | |
| SCHEMBL29663816 | 0.81 | HTR6 (0.47) | HTR6SIGMAR1HTR7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4127578-A | Diene intermediates for indantetrols | E. R. SQUIBB & SONS, INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4092318-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4044040-A | HYPERTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-08-23 | — | — | US | disclosed |